ACP recently received a concern from a veterinarian about the risks of pets being exposed to topical nonsteroidal anti-inflammatory drug (NSAID) products, either over the counter or prescribed in higher concentrations. The veterinarian said she has seen several cases of accidental exposure to diclofenac leading to acute kidney injuries to cats with varying degrees of patient outcome success.
According to the American Society for the Prevention of Cruelty to Animals (ASPCA), compounded topical creams or ointments that contain NSAIDs, such as diclofenac, can be toxic to pets. Ingestion of even a small amount of human topical cream can lead to serious issues, especially in cats. A small exposure can include a pet licking their owner’s skin after a recent application of the product. This exposure can lead to acute kidney failure and death can occur without immediate treatment after exposure.[1]
Before dispensing these products, pharmacy teams are encouraged to check with patients if they have pets in the home and discuss the risks for patient awareness. The use of an additional warning label on the packaging may also help create awareness for the patient.
[1] https://www.aspca.org/news/topical-creams-can-pose-danger-pets retrieved May 11, 2026.
